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About Celaid

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Update treatments using
hematopoietic stem cells

Until now, many kinds of new therapies have been developed along with the advancement of medical technology, and cancer is no longer the incurable disease that it once was. Nevertheless, though the cure rate for cancers of the blood, such as leukemia and malignant lymphoma, etc., has improved thanks to the emergence of new therapies, blood cancer is still said to be very difficult to treat, and new therapies are always needed.

Therefore, in recent years, the application of new therapies utilizing hematopoietic stem cells (HSCs) in medical treatment has attracted much attention. In particular, the application of HSCs, which are the source of blood, has long been used in the treatment of blood disorders. In addition, due to the great usefulness of HSCs, research and development are being conducted throughout the world into new applications, such as in the treatment of genetic disorders, etc. However, in any therapy, it is necessary to prepare a large amount of good quality HSCs that is suitable for the patient at the time of treatment. In current clinical practice, it is difficult to secure the necessary amount of the right kind of cells and, for various reasons, such as the difficulty of artificial in vitro expansion, the benefits of HSCs cannot be fully leveraged.

Against the backdrop of this difficult challenge of trying to secure adequate amounts for the utilization of HSCs, we have been successful in developing a series of new technologies, replacing the albumin that was previously said to be essential for the culture of HSCs with polyvinyl alcohol, demonstrating in mice a game-changing technology that significantly increases the ability to expand HSCs*1, and a "Method for the large volume in-vitro expansion of human hematopoietic stem cells"*2,3,4.
Through these technological developments, we have been able to take small amounts of HSCs from biological samples and expand them into large quantities in-vitro, and have confirmed that the cells can be safely transplanted and engrafted into living organisms while maintaining their stem cell characteristics (stemness).

Leveraging this technology, our aim is to propose new medical technologies that have never been seen before in new fields, such as medical treatment and gene therapy currently using HSCs, and to enrich the quality of life of people all around the world.

  • *1 Adam et. al., Long -term ex vivo hematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019 Jul.
  • *2 Sakurai et. al., In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide. Int J Hematol. 2020 Mar.
  • *3 WO 2021/049617
  • *4 WO 2021/149799
Representative Director and CEO Nobuyuki Arakawa
MANAGEMENT PHILOSOPHY

VISION, VALUE, MISSION
COMPANY PROFILE

Company name Celaid Therapeutics Inc.
Established October 8, 2020
Representative
Director & CEO
Nobuyuki Arakawa
Paid-in capital 460,003,200 JPY(Including capital reserve)
Address <Headquarters / Lab.>
Utokyo Entrepreneur Lab., South Clinical Research Bldg., 7-3-1 Hongo,Bunkyo-ku, Tokyo 113-8485, Japan
<Tokyo office>
Inspired.Lab., 6F Otemachi Bldg., 1-6-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan
<Kobe office>
International Medical Device Alliance Center 5F, 1-6-5 Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Business
  • Human hematopoietic stem cell propagation reagents
  • Cell manufacture and sales
  • Development of regenerative medical products using human hematopoietic stem cells
  • Development of next-generation medical therapies, such as gene therapy, etc.
ACCESS

< Headquarters / Lab. >

  • Tokyo Metro Marunouchi Line [ Hongo Sanchome Station ]
    Take Exit 2 and turn right at the Hongo Sanchome intersection, turn left at the Motofuji Police Station intersection,
    and enter the campus from the Tatsuokamon gate.
  • Tokyo Metro Chiyoda Line [ Yushima Station ]
    Take Exit 1 and turn right at the Motofuji Police Station intersection, and enter the campus from the Tatsuokamon gate.
  • Toei Ōedo Line [ Hongo Sanchome Station ]
    Turn left at the Motofuji Police Station intersection, and enter the campus from the Tatsuokamon gate.

<Tokyo office>

  • Direct connection to Otemachi Station. The nearest exits are C7 and E2. Please use the elevator to the east (Tokyo Station side).

<Kobe office>

  • 3 minutes walk from Port Liner Medical Center Station.
MEMBER

渡部 素生

Motoo Watanabe

Ph.D: Co-founder, Chairman of the Board & CSO

After graduating from the Faculty of Agriculture of the University of Tokyo, engaged in molecular immunology research with Mitsubishi Yuka (currently Mitsubishi Chemical), the Ontario Cancer Institute in Toronto, Canada, and Mount Sinai Hospital. After working at the Mitsubishi Kagaku Institute of Life Sciences, served as CEO of CellFree Sciences Co., Ltd., Technical Counselor of the Japan Science and Technology Agency, and CTO of Megakaryon Corporation. In addition to involvement in bio-venture technology management, participated in the development of the founding technology of Celaid at the Institute of Medical Science, the University of Tokyo. In 2020, co-founded Celaid and was appointed Chairman of the Board and CSO. Doctor of Medicine.

荒川 信行

Nobuyuki Arakawa

Co-founder, Representative Director & CEO

After graduating from the Faculty of Science and Technology and the Graduate School of Science and Technology (Master of Engineering) of Keio University, worked as a consultant in manufacturing and retail at Accenture Co., Ltd. Subsequently, accumulated a wealth of experience from large corporations in the management and reform of venture businesses and SMEs, including the launch of university-backed bio ventures, and business development and DX promotion, etc., of technology companies in the fields of AI, IoT and healthcare. Co-founder of Celaid in 2020, appointed Representative Director and CEO.

井上 雄介

Yusuke Inoue

COO & CFO

Yusuke Inoue joined Celaid Therapeutics in Apr 2022 as Chief Operating and Financial Officer, bringing more than 13 years of global pharmaceutical sector industry experience. Prior to Celaid, Yusuke served as Global R&D Gastrointestinal (GI) Portfolio & Finance Lead in Boston, USA at Takeda Pharmaceuticals, controlling hundreds million dollars R&D investments and seventeen global assets with over 10 alliance partners by engaging his GI finance team. Prior to his role in Boston, Yusuke served as Oncology Portfolio & Finance Lead in Japan, Japan Program Manager in Cardiovascular and Metabolism areas, Project Management Office, and Clinical Operation in Neuroscience therapeutic area.Yusuke holds a master of Bioengineering and a Bachelor of Biotechnology from Tokyo Institute of Technology.

小原 洋志

Hiroshi Kohara

CTO (Chief Technology Officer) / General Manager of R&D Division

After graduating from the Faculty of Science and Technology, the Graduate School of Science and Technology, Keio University and the Graduate School of Medicine, Kyoto University,worked as a postdoctoral research fellow at the Institute for Frontier Medical Sciences (currently Institute for Life and Medical Sciences), Kyoto University, Brigham and Women's Hospital and Harvard Medical School. Also worked as Project Senior Assistant Professor at Medical Institute of Bioregulation, Kyushu University and Institute of Medical Science, University of Tokyo, as Principal Scientist at Takeda Pharmaceutical Company Limited. During this time, accumulated a rich experience in leading researches in the fields of Hematology and therapeutic researches for congenital hematologic disorders in academia, and investigative toxicology studies for de-risking and mechanistic elucidation of toxicities such as drug-induced hematological toxicities and liver toxicities in pharmaceutical industry. Joined Celaid Therapeutics in Nov 2021 as General Manager at Research & Development Division, also serve as Chief Technology Officer from Apr 2022.

SCIENTIFIC ADVISORS

中内 啓光

Hiromitsu Nakauchi

MD, Ph.D: Co-founder
  • Specially Appointed Professor, Division of Stem Cell Therapy, The Institute of Medical Science, University of Tokyo
  • Professor, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University

Satoshi Yamazaki

Ph.D: Co-founder
  • Professor, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba
  • Specially Appointed Associate Professor, Stem Cell Therapy Laboratory, The Institute of Medical Science, University of Tokyo
櫻井 政寿

Masatoshi Sakurai

D, Ph.D: Co-founder
  • Full-time lecturer, Division of Hematology Department of Internal Medicine Keio University School of Medicine

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